Medication Monitor

Generic Name (Trade Name—Company)
June 2, 2011

Angiotensin receptor blockers (ARBs)

(Various trade names—Various manufacturer)
Not associated with increased cancer risk

The results of FDA’s comprehensive trial-level meta-analysis of data from 31 trials involving approximately 156,000 patients showed that patients taking an ARB did not have an increased risk of cancer, compared with those on non-ARB therapy. FDA found no evidence of an association between ARBs and cancer-related death, breast cancer, lung cancer, or prostate cancer. In July 2010, FDA stated that it would conduct this review after a published meta-analysis of 5 randomized clinical trials reported a small but statistically significant increase in the risk of cancer in patients taking ARBs.