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High-Risk Older Patients Benefit from ACE Inhibition


ACE inhibitor therapy should be considered in all older patients who have (1) diabetes or any vascular disease (coronary artery disease, stroke, peripheral vascular disease) plus (2) one other risk factor for cardiovascular disorders (hypertension, high total cholesterol, low HDL cholesterol, cigarette smoking, or microalbuminuria).


Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting enzyme inhibitor, ramipril, on death from cardiovascular causes, myocardial infarction, and stroke in high-risk patients. N Engl J Med. 2000(Jan 20);342. Study released early via the Journal’s Web site.

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