Drug Interactions Corner

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Antithrombotic polypharmacy increases bleeding complications after first myocardial infarction


According to a study recently published in Lancet, patients who have suffered a first-time myocardial infarction are more likely to be readmitted to the hospital with a bleeding complication when they are prescribed triple therapy (aspirin, clopidogrel, and vitamin K antagonist) or dual therapy with clopidogrel plus vitamin K antagonist than when they receive monotherapy with either aspirin, clopidogrel, or a vitamin K antagonist.