Drug Interactions Corner

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Are children more vulnerable than adults to drug-drug interactions?

KEY POINT

A recent analysis of 145 published drug–drug interaction studies (including case reports) in pediatric populations confirmed that limited data are available in children less than 2 years of age, making it difficult to compare findings from studies in pediatric groups to those in adults. More studies are needed to confirm or refute the existence of suspected age-related differences in interaction susceptibility and severity.