Drug Interactions Corner

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Clopidogrel and statins: A noninteraction?

KEY POINT

Another large study adds to the growing confusion regarding the extent and clinical significance of an interaction between clopidogrel and the HMG-CoA reductase inhibitors (statins).

SOURCES

Saw J et al. Lack of evidence of a clopidogrel–statin interaction in the CHARISMA trial. J Am Coll Cardiol 2007;50:291–5.

Angiolillo DJ, Alfonso F. Clopidogrel–statin interaction: myth or reality? J Am Coll Cardiol. 2007;50:296–8.