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Drug interactions with St. John’s wort vary with hyperforin content


A recent review of the literature suggests that St. John’s wort products with low hyperforin content have fewer drug interactions, whereas higher hyperforin contents are associated with numerous documented drug interactions.


Vlachojannis J et al. Drug interactions with St. John’s wort products [letter]. Pharmacol Res. 2011;63:254–6.

Borrelli F et al. Herb-drug interactions with St John’s wort (Hypericum perforatum): an update on clinical observations. AAPS J. 2009;11(4):710–27.