Drug Interactions Corner

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Gemfibrozil increases activity of glitazones

KEY POINT

An interaction involving the cytochrome P450 (CYP)2C8 isoenzyme can produce clinically relevant increases in the area under the serum concentration–time curves (AUCs) for rosiglitazone (Avandia— GlaxoSmithKline) and pioglitazone (Actos—Lilly) when gemfibrozil is used concomitantly.