Drug Interactions Corner

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Methadone’s effects on the QTc interval


In a small, short-term study, administration of (R)-methadone resulted in a decrease in the QTc interval, whereas administration of the chiral mixture (R,S)-methadone increased the QTc interval.


Ansermot N et al. Substitution of (R,S)-methadone by (R)-methadone: impact on QTc interval. Arch Intern Med. 2010;170:529–36.

Krantz MJ et al. QTc interval screening in methadone treatment. Ann Intern Med. 2009;150:387–95.