Drug Interactions Corner

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New mechanisms for statin drug interactions explored

KEY POINT

Drugs that are inhibitors of cytochrome P450 (CYP) enzymes, particularly CYP3A4, are known to increase serum concentrations of several of the HMG-CoA reductase inhibitors (“statins”), thus increasing the risk for myopathy. New mechanisms involving membrane transport molecules are coming to light that explain interactions between the statins and other drugs.

SOURCES

Neuvonen PJ et al. Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006;80:565–81.

Holtzman CW et al. Role of P-glycoprotein in statin drug interactions. Pharmacotherapy. 2006;26:1601–7.