Drug Interactions Corner

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Older patients: Interactions problematic


Patients aged 65 and older are particularly susceptible to drug–drug interactions because of pharmacokinetic and pharmacodynamic changes, polypharmacy, and comorbidities. Pharmacists need to be able to recognize potential drug interactions and take the necessary steps to prevent adverse events.


Mahmood M et al. Potential drug–drug interactions within Veterans Affairs medical centers. Am J Health Syst Pharm. 2007;64:1500–5.

Johnell K et al. Inappropriate drug use in the elderly: a nationwide register-based study. Ann Pharmacother. 2007;41:1243–8.

Mallet L et al. The challenge of managing drug interactions in elderly people. Lancet. 2007;370:185–91.