Ondansetron decreases tramadol effectiveness after surgery
KEY POINT
The analgesic efficacy of tramadol was reduced with the concurrent administration of ondansetron in the early postoperative period, according to results of a systematic review and meta-analysis.
SOURCES
Stevens AJ et al. The effect of ondansetron on the efficacy of postoperative tramadol: A systematic review and meta-analysis of a drug interaction. Anaesthesia. 2015;70:209–18.
