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St. John’s Wort Interacts with Imatinib Through 3A4 Induction


St. John’s wort, through its induction of the cytochrome P450 3A4 enzymes, reduces serum concentrations of imatinib (Gleevec—Novartis). Concomitant use of the dietary supplement and antineoplastic medication should be avoided.


Smith P. The influence of St. John’s wort on the pharmacokinetics and protein binding of imatinib mesylate. Pharmacotherapy. 2004;24:1508–14.