Drug Interactions Corner

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Sulfonylurea + sulfa antibiotic: Increased hypoglycemia risk


Results of a recent study involving Medicare beneficiaries suggested that the risk of hypoglycemia is increased with the coadministration of trimethoprim/sulfamethoxazole antibiotics and sulfonylureas. Coadministration is more likely to occur in patients having a greater number of different prescribers and receiving polypharmacy.


Tan A et al. Coadministration of co-trimozxazole with sulfonylureas: hypoglycemia events and pattern of use. J Gerontol A Biol Sci Med Sci. 2014; [Epub ahead of print].

Juurlink DN et al. Drug–drug interactions among elderly patients hospitalized for toxicity. JAMA. 2003;289(13):1652-1658.

Schelleman H et al. Anti-infectives and the risk of severe hypoglycemia in users of glipizide or glyburide. Clin Pharmacol Ther. 2010;88(2):214–222.