Drug Interactions Corner

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Tadalafil, Vardenafil Subject to PDE 5 Drug Interactions

KEY POINT

As clinicians incorporate the two recently approved phosphodiesterase 5 (PDE 5) inhibitors into their care of men with erectile dysfunction, they must be aware of the drugs’ interactions with imidazole antifungal agents, protease inhibitors, and other strong inhibitors of the cytochrome P450 (CYP) 3A4 isoenzyme.

SOURCES

Lexi-Interact. Phosphodiesterase 5 inhibitors/protease inhibitors. Hudson, Ohio: Lexi-Comp, Inc.; 2004.

Lexi-Interact. Phosphodiesterase 5 inhibitors/antifungal agents (imidazole). Hudson, Ohio: Lexi-Comp, Inc.; 2004.