Drug Interactions Corner

Back to articles

Tadalafil, Vardenafil Subject to PDE 5 Drug Interactions


As clinicians incorporate the two recently approved phosphodiesterase 5 (PDE 5) inhibitors into their care of men with erectile dysfunction, they must be aware of the drugs’ interactions with imidazole antifungal agents, protease inhibitors, and other strong inhibitors of the cytochrome P450 (CYP) 3A4 isoenzyme.


Lexi-Interact. Phosphodiesterase 5 inhibitors/protease inhibitors. Hudson, Ohio: Lexi-Comp, Inc.; 2004.

Lexi-Interact. Phosphodiesterase 5 inhibitors/antifungal agents (imidazole). Hudson, Ohio: Lexi-Comp, Inc.; 2004.