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Tenofovir–diclofenac interaction linked to increased kidney injury risk

KEY POINT

According to a recent study, patients treated with a combination antiretroviral therapy regimen that included tenofovir (Viread—Gilead) who were also taking diclofenac for at least 6 months were at increased risk for acute kidney injury (AKI). Study participants with pre-existing hypophosphatemia also had a higher risk for AKI.

SOURCES

Bickel M et al. Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration. HIV Medicine. 2013;14(10):633–638.