Drug Interactions Corner

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Tolterodine–warfarin interaction raises INRs

KEY POINT

Several case reports suggest that a potential drug interaction between tolterodine (Detrol/Detrol LA—Pfizer) and warfarin may exist. This interaction may lead to elevated international normalized ratios (INRs).

SOURCES

Taylor JR. Probable interaction between tolterodine and warfarin. Pharmacotherapy. 2006;26:719–21.

Colucci VJ, Rivey MP. Tolterodine–warfarin drug interaction. Ann Pharmacother. 199;33:1173–6.