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Use of macrolides with statins linked to increased risk of statin toxicity, death

KEY POINT

In older adults, coprescription of simvastatin, lovastatin, or atorvastatin with clarithromycin or erythromycin was associated with increased risk of hospitalization with rhabdomyolysis or acute kidney injury, and all-cause mortality.

SOURCES

Patel AM et al. Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study. Ann Intern Med. 2013;158: 869–76.