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Long-term bisphosphonate use associated with higher fracture risk


In older women at high risk for fracture, use of bisphosphonates for 10 to 13 years was associated with a higher risk of any clinical fracture compared with use for 2 years, according to results of a retrospective analysis of data from the Women’s Health Initiative (WHI) study.


Drieling RL, et al. Long-term oral bisphosphonate therapy and fractures in older women: the Women’s Health Initiative. J Am Geriatr Soc. 2017;65(9):1924–31.

Lyles KW. Have we learned how to use bisphosphonates yet? J Am Geriatr Soc. 2017;65(9):1902–3.

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