Endocrinology

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Obesity in children alters drug exposure, pharmacokinetics

KEY POINT

A systematic review of 20 studies revealed clinically significant pharmacokinetic alterations in children compared with control participants who were not obese for more than one-half of the drugs studied, with meaningful differences in drug exposure seen in approximately 40% of drugs studied.

SOURCES

Harskamp-van Ginkel MW et al. Drug dosing and pharmacokinetics in children with obesity: a systematic review. JAMA Pediatr. 2015;169:678–85.

Gillman MW et al. Children with obesity: how are they different [Editorial]? JAMA Pediatr. 2015;169:626–8.