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Patients with impaired acid secretion may require increased doses of thyroxine


According to a study recently reported in the New England Journal of Medicine, patients with goiter who have impaired gastric acid secretion require increased doses of thyroxine (Eutirox—Bracco), suggesting that normal gastric acid secretion is necessary for effective absorption of oral thyroxine.


Centanni M et al. Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis. N Engl J Med. 2006;354:1787–95.

Utiger RD. Estrogen, thyroxine binding in serum, and thyroxine therapy [editorial]. N Engl J Med. 2001;344:1784–5.

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