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STAR shines on raloxifene


The Study of Tamoxifen and Raloxifene (STAR) has shown that while both drugs are effective in reducing the incidence of invasive breast cancer by 50% (17 cases or 2% per group), taking raloxifene (Evista—Lilly) 60 mg orally daily is associated with 36% fewer cases of uterine cancer (0.48% vs. 0.76%, P = 0.07), 29% less cases of thromboembolism (0.7% vs. 0.9%, P = 0.01), and a 21% lower rate of cataract development (3.2% vs. 4.1%, P = 0.002) than tamoxifen 20 mg orally daily.


Vogel VG et al. Effects of tamoxifen and raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP study of tamoxifen and raloxifene (STAR) P-2 trial. JAMA. 2006;295:2727–41.

Gradishar WJ, Cella D. Selective estrogen receptor modulators and prevention of breast cancer. JAMA. 2006;295:2785–6.

National Breast Cancer Coalition. The STAR trial: raloxifene versus tamoxifen for breast cancer risk reduction. 2006.

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