Endocrinology

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Testosterone effects and duration of exposure

KEY POINT

Long-term exposure of testosterone replacement therapy was associated with a lower risk of death, cardiovascular (CV) events, and prostate cancer, whereas shorter durations of therapy increased the risk of death and CV events, according to results of an observational cohort study published online in The Lancet Diabetes and Endocrinology.

SOURCES

Wallis CJD, et al. Survival and cardiovascular events in men treated with testosterone replacement therapy: An intention-to-treat observational cohort study. Lancet Diabetes Endocrinol. 2016;[Epub ahead of print].

Lauer MS. Testosterone replacement therapy: intent matters. Lancet Diabetes Endocrinol. 2016;[Epub ahead of print].