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Atopic Dermatitis in Infants: Early Antihistamine Therapy Prevents Progression to Asthma

KEY POINT

While by no means a final solution to a vexing problem, antihistamine therapy for infants with atopic dermatitis is showing promise for delaying or even preventing progression to asthma. The protective effect is especially apparent in infants who are sensitive to house dust mite, grass pollen, or both.

SOURCES

Warner JO for the ETAC Study Group. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up. J Allergy Clin Immunol. 2001;108:929–37. 

Simons FER for the ETAC Study Group. Prospective, long-term safety evaluation of the H1-receptor antagonist cetirizine in very young children with atopic dermatitis. J Allergy Clin Immunol. 1999;104:433–40.