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Leukotriene Antagonist, Antihistamine Symbiotic in Combination Therapy


In patients whose asthma is not completely controlled by montelukast (Singulair—Merck) alone, addition of the histamine-1 antagonist loratadine (Claritin—Schering) can produce significantly improved pulmonary function.


Reicin A et al. Montelukast, a leukotriene receptor antagonist, in combination with loratadine, a histamine receptor antagonist, in the treatment of chronic asthma. Arch Intern Med. 2000;160:2481–8.

Malmstrom K et al. Effects of montelukast (a leukotriene receptor antagonist), loratadine, montelukast+loratadine and placebo in seasonal allergic rhinitis and conjunctivitis [abstract]. Allergy Clin Immunol. 1998;406:S97.