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Vitamin E Fails to Affect Outcomes in Patients with Diabetes


Cardiovascular outcomes, microvascular complications, and glycemic control were not significantly altered by daily administration of vitamin E 400 IU. Data from the Heart Outcomes Prevention Evaluation (HOPE) trial and the Microalbuminuria Cardiovascular Renal Outcomes (MICRO-HOPE) substudy fail to support use of the supplement in patients with type 1 or type 2 diabetes mellitus.


Lonn E et al. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care. 2002;25:1919–27.