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Vaccines and biologics: Can they mix?


According to a recent systematic review, patients with stable autoimmune rheumatic diseases (AIRDs) who are taking biologic agents (e.g., antitumor necrosis factor [TNF] inhibitors) are eligible to receive many inactivated vaccines, such as influenza and pneumococcal. Live vaccines should generally be avoided in these patients; little data exist to guide administration of some others vaccines, including hepatitis A and hepatitis B.


Ferreira I et al. Vaccines and biologics. Ann Rheum Dis. 2014;73:1446–1454.