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Crohn’s Disease: Immunogenicity of Infliximab Requires Attention


Administration of single induction doses of infliximab (Remicade—Centocor) at times when patients with Crohn’s disease are not on immunosuppressive agents can lead to development of antibodies to the chimeric monoclonal antibody itself. When antibodies to infliximab (ATI) are present in high concentrations, patients have shortened duration of benefit, complete loss of response, and/or infusion reactions to infliximab.


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