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C. difficile Colitis Treatment Failures Rising with Metronidazole


Recent studies point to poorer outcomes and increased relapses when metronidazole has been used to treat Clostridium difficile colitis infections.


Musher DM et al. Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole. Clin Infect Dis. 2005;40:1586–90.

Pépin J et al. Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin Infect Dis. 2005;40:1591–7.

Gerding DN. Metronidazole for Clostridium difficile—associated disease: is it OK for mom [editorial]? Clin Infect Dis. 2005;40:1598–600.

Schroeder MS. Clostridium difficile–associated diarrhea. Am Fam Physician. 2005(Mar 1);71(5):921–8.