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New Studies Add Complexity to Relationship Among Helicobacter pylori, NSAIDs, and Peptic Ulcers


Does Helicobacter pylori infection along with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) increase the risk of peptic ulcers? Yes, according to recent studies—and eradication of the pathogen can reduce the risk when long-term NSAID therapy is needed.


Chan FKL et al. Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomized trial. Lancet. 2002:359:9–13.

Huang J-Q et al. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic ulcer disease: a meta-analysis. Lancet. 2002:359:14–22.

Pounder RE. Helicobacter pylori and NSAIDs—the end of the debate [editorial]? Lancet. 2002:358:3–4.