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Oral PPIs as effective as I.V. PPIs for bleeding peptic ulcers


Use of oral proton pump inhibitors (PPIs) compared with I.V. PPIs resulted in similar outcomes in patients with peptic ulcer bleeding in rate of recurrent bleeding, mortality rate, blood transfusions within 30 days of follow-up, and overall length of hospital stay, according to results of a meta-analysis published in the British Journal of Clinical Pharmacology.


Jian Z, et al. Is the era of intravenous proton pump inhibitors coming to an end in patients with bleeding peptic ulcers? Meta-analysis of the published literature. Br J Clin Pharmacol. 2015; [Epub ahead of print].

Laine L, et al. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012;107:345–360.