Back to articles

PPIs Should Be Taken with Meals, But Few Patients Do So


The unique pharmacologic properties of the proton-pump inhibitors (PPIs) make administration just before a meal highly advantageous. But, according to a recent survey, only 12% of patients were taking the agent during the preferred 15–30 minutes before meals.


Sachs G. Proton pump inhibitors and acid-related diseases. Pharmacotherapy. 1997;17:22–27.

Hatlebakk JG et al. Proton pump inhibitors: better acid suppression when taken before a meal than without a meal. Aliment Pharmacol Ther. 2000;14:1267–72.

Gunaratnam NT et al. Proton pump inhibitor dosing habits in one hundred sequential community-based GERD patients. Paper presented at: Digestive Disease Week; May 20–23, 2001; Atlanta, Ga.