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Previous acid suppressive therapy linked to lower vitamin B12 levels


Current or previous use of proton pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs) for at least 2 years of a 12-year study period was significantly associated with an increased risk of vitamin B12 deficiency. This association was stronger with higher daily doses of acid-suppressive therapy, younger patients, and in women.


Lam JR et al. Proton pump inhibitor and histamin 2 receptor antagonist use and vitamin B12 deficiency. J Am Med Assoc. 2013;310:2435–42.

Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013;368:149–60.