Gastroenterology

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Proton pump inhibitors should be used in older adults receiving antiplatelet therapy

KEY POINT

Patients who received aspirin-based antiplatelet treatment after a vascular event and were not on routine proton pump inhibitors (PPIs), particularly those who were 75 years of age or older, were at an increased risk of major bleeding, including disabling or fatal upper gastrointestinal (GI) bleeding, suggesting that coprescription with a PPI should be used in these patients to reduce the risk of adverse bleeding events.