SSRIs + NSAIDs: Increased risk for GI bleeding
KEY POINT
Selective serotonin reuptake inhibitors (SSRIs) were associated with a modestly increased risk of upper gastrointestinal (GI) bleeding in a recent study. This risk was further elevated in patients taking concomitant NSAIDs.
SOURCES
Anglin R et al. Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis. Am J Gastroenterol. 2014;109:811–819.
