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SSRIs + NSAIDs: Increased risk for GI bleeding

July 21, 2014
  • Advising on this article:
  • C. Wayne Weart
  • M. Lynn Crismon
  • Arthur A. Schuna

KEY POINT

Selective serotonin reuptake inhibitors (SSRIs) were associated with a modestly increased risk of upper gastrointestinal (GI) bleeding in a recent study. This risk was further elevated in patients taking concomitant NSAIDs.

SOURCES

Anglin R et al. Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis. Am J Gastroenterol. 2014;109:811–819.

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