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Nephrology

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May 7, 2018

Balanced crystalloids may be preferred to I.V. saline

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Two large, single-center trials published in theNew England Journal of Medicine comparing balanced crystalloid solutions with saline in both noncritically ill and critically ill adults...
April 24, 2018

Trimethoprim is associated with negative renal outcomes in older adults

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Use of trimethoprim for management of urinary tract infections (UTIs) in older adults was associated with a higher risk of acute kidney injury (AKI) and hyperkalemia compared with other...
April 10, 2018

No renal benefits with sodium bicarbonate or acetylcysteine before angiography

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In patients at high risk of renal complications who are undergoing angiography, use of I.V. sodium bicarbonate offered no benefits for prevention of contrast-associated acute kidney injury...
December 26, 2017

Sertraline ineffective for treating major depression in patients with advanced CKD

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Daily use of sertraline in patients with major depressive disorder (MDD) and CKD who were not dialysis dependent was no more effective than placebo at treating depression and resulted in a greater...
August 1, 2017

Antibiotic-associated adverse effects common in hospitalized patients

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Results of a retrospective cohort analysis at a large academic medical center showed that gastrointestinal (GI), renal, and hematologic abnormalities were common adverse events (AEs) in...

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APhA DrugInfoLine (ISSN 2162-3015) is a weekly publication of, and is owned and copyrighted by the American Pharmacists Association, the national professional society of pharmacists. Materials in APhA DrugInfoLine do not neccessarily represent the policy, recommendations, or endorsement of APhA. The publisher, authors, editors, reviewers, and contributors have taken care to ensure that the information contained in APhA DrugInfoLine is accurate and current; however, they shall have no ability to any person or entity with regard to claims, losses, or damage caused or alleged to be caused, directly or indirectly by use of any information contained in the publication. All decisions about drug therapy must be based on independent judgement of the clinician.