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No renal benefits with sodium bicarbonate or acetylcysteine before angiography


In patients at high risk of renal complications who are undergoing angiography, use of I.V. sodium bicarbonate offered no benefits for prevention of contrast-associated acute kidney injury compared with I.V. sodium chloride. Similarly, a lack of effect was observed with use of oral acetylcysteine compared with placebo, according to results of the PRESERVE trial published in the New England Journal of Medicine.



Weisbord SD, et al. Outcomes after angiography with sodium bicarbonate and acetylcysteine. N Engl J Med. 2018;378(7):603–14. 

Rosner MH. Prevention of contrast-associated acute kidney injury. N Engl J Med. 2018;378(7):671–2.