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Trimethoprim is associated with negative renal outcomes in older adults


Use of trimethoprim for management of urinary tract infections (UTIs) in older adults was associated with a higher risk of acute kidney injury (AKI) and hyperkalemia compared with other antibiotics (i.e., ciprofloxacin, cephalexin, nitrofurantoin, amoxicillin), according to results of an observational cohort study published in BMJ. These data support the theory that the trimethoprim component of trimethoprim–sulfamethoxazole has been implicated in other studies in the United States.