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Teratogenic risk of antiepileptic drugs assessed


A prospective analysis of data from a European pregnancy registry of antiepileptic drugs published in Lancet Neurology showed that use of valproate had the highest prevalence of major congenital abnormalities (10.3%), whereas agents such as oxcarbazepine (3.0%), lamotrigine (2.9%), and levetiracetam (2.8%) had the lowest prevalence. Also, dose dependency in prevalence was noted for select agents, with higher dosages having greater teratogenic risks than lower dosages.