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Irinotecan: New Agent for Metastatic Colorectal Cancer


Weekly treatments of irinotecan (Camptosar—Pharmacia) are being added to chemotherapy regimens for patients with metastatic colorectal cancer. A topoisomerase I inhibitor, irinotecan provides the first advance in therapy for this condition since the development of fluorouracil.


Saltz LB et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med. 2000;343:905–14.

Mayer RJ. Moving beyond fluorouracil for colorectal cancer [editorial]. N Engl J Med. 2000;343:963–4.