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Genotype-guided warfarin dosing resulted in better outcomes in elective surgical procedures

KEY POINT

Genotype-guided warfarin dosing for patients undergoing elective hip or knee arthroplasty resulted in a reduced risk of the composite of major bleeding, elevated international normalized ratio (INR), venous thromboembolism (VTE), or death compared with clinically guided dosing, according to results of the Genetic Informatics Trial (GIFT) published in JAMA.